GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10518128 | 1 | rs9998442 | chr4:75706141 | BTC | chr4:75671448-75719882:- | 0.2 | 3.88 | 0.00012 | Electroencephalogram traits |
| THCA | cis | rs1061377 | 1 | rs9998481 | chr4:39118835 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.77 | 1.47E-8 | Uric acid levels |
| THCA | cis | rs1061377 | 1 | rs9998867 | chr4:39119162 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.77 | 1.47E-8 | Uric acid levels |
| THCA | cis | rs1061377 | 1 | rs9999327 | chr4:39111731 | KLHL5 | chr4:39046659-39123828:+ | -0.21 | -5.73 | 1.77E-8 | Uric acid levels |
| THCA | trans | rs10037055 | 1 | rs10037055 | chr5:176691279 | LOC388955 | chr2:63849182-63850159:- | -0.73 | -19.34 | 5.71E-62 | Migraine without aura |
| THCA | trans | rs1056667 | 1 | rs10214634 | chr6:26564582 | ZNF322B | chr9:99957633-99961910:- | 0.58 | 11.37 | 1.09E-26 | Educational attainment |
| THCA | trans | rs853679 | 1 | rs10456362 | chr6:28221816 | BTN3A2 | chr6:26365398-26378546:+ | 0.43 | 8.7 | 5.47E-17 | Depression |
| THCA | trans | rs1056667 | 1 | rs10484442 | chr6:26555879 | ZNF322B | chr9:99957633-99961910:- | 0.57 | 10.95 | 4.62E-25 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs1056667 | chr6:26510564 | ZNF322B | chr9:99957633-99961910:- | 0.55 | 10.32 | 1.08E-22 | Educational attainment |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | ABCC11 | chr16:48200822-48281479:- | 0.29 | 5.89 | 7.21E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | BMPR1A | chr10:88516396-88684944:+ | -0.25 | -6.4 | 3.76E-10 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | CLDN2 | chrX:106143394-106174091:+ | 0.26 | 6.09 | 2.26E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | EFNB2 | chr13:107142098-107187337:- | -0.25 | -6 | 3.85E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | EML5 | chr14:89081205-89259157:- | 0.3 | 6.84 | 2.44E-11 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | EPDR1 | chr7:37960163-37991539:+ | 0.33 | 7.43 | 5.06E-13 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |